Webhow to take it. Take sertraline once a day. You can take it with or without food. You can choose to take sertraline at any time, as long as you stick to the same time every day. Weboct 1, 2024 · take this medicine on an empty stomach. Do not take this medicine with food or right after a meal because it may not work as well. Do not take this medicine if you. Weboct 1, 2024 · if you take them together or do not wait 14 days, you…